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This section of the problem regulates reward responses in getting food and sex, as well as in nurturing infants and children. One of the most important neurotransmitters linked to reward responses, both when they malfunction and whenever they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the volume of dopamine released in responding to a stimulus"(Bostwick & Bucci, 2008). Using two separate drugs to lose weight naturally can be very effective you'll find combinations in front of the FDA now awaiting approval. When dealing with weight-loss and the people that go through it one should err to the side of caution and let the FDA do its job and demand some research be done so the public knows the side effects and risks of the medications before we take them. Keep in mind that drug companies are in business to generate income and that they would say anything to keep people on his or her medications. Researchers found that participants taking this drug for a year, dropped excess weight within four weeks and have kept the extra weight off throughout the 56 weeks in the study. Contrave is a combination with the drugs naltrexone and bupropion, which generally seems to reflect a fresh trend of weight-loss drugs which are made up of many active ingredient, which may make them more potent and safer. Combo-pilling could be the newest fad or also the newest in the future under scrutiny and thus it is just more publicly known lately, comb-pilling for losing weight has been around since the eighties. The biggest reason that by using a combination of pills is starting to become popular is the fact that as of right now there are no long term prescription weight loss supplements that have been approved by the FDA apart from orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications and some of the combinations are actually rejected or have yet to be approved by the FDA. Seizures can be a side effect with Contrave and must not be taken in people who have seizure disorders. The drug can also raise blood pressure level and pulse rate, and mustn't be used in people who have a history of cardiac arrest or stroke in the earlier six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy with all the drug. The FDA also warned that Contrave can raise hypertension and heartbeat and must 't be used in patients with uncontrolled high blood pressure levels, in addition to by anyone with heart-related and cerebrovascular (circulatory dysfunction impacting the brain) disease. Patients with a history of cardiac arrest or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes using a boxed warning to alert physicians and patients on the increased likelihood of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for stopping smoking. The most common unwanted side effects with Contrave include nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea.