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Some possible triggers might include: Using two separate drugs to shed weight can be very effective there are combinations while watching FDA now awaiting approval. When dealing with fat loss and the individuals who go through it you need to err along the side of caution and permit the FDA do its job and demand some study be done so that the public knows the side effects and risks of the medications before we take them. Keep in mind that drug companies will be in business to generate money and that they would say almost anything to keep people on his or her medications. Researchers discovered that participants investing in this drug for any year, lost excess weight within a month and have kept the extra weight off through the 56 weeks with the study. Contrave is a combination with the drugs naltrexone and bupropion, which appears to reflect a fresh trend of weight-loss drugs which are made up of many active ingredient, which may make them more efficient and safer. Combo-pilling could be the newest fad or better yet the newest into the future under scrutiny and thus it is just more publicly known lately, comb-pilling for weight loss has been around since the eighties. The biggest reason that using a combination of pills is starting to become popular could be the fact that since right now there are not any long term prescription slimming capsules that have been approved by the FDA besides orlistat. The truly disturbing part is doctors are prescribing these combinations of medications even though some of the combinations happen to be rejected or have yet to be approved by the FDA. Seizures certainly are a side effect with Contrave and must not be taken in people who have seizure disorders. The drug can also raise blood pressure level and heartbeat, and shouldn't be used in individuals with a history of heart attack or stroke in the last six months. 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